Streamlining the Decision-Making Process on Tubular Rigid Busbar Selection During the Planning / Designing Stage by Utilizing 3D Substation BIM Design Software

For Utilities, each substation is regarded as an asset. Managing of assets is one of domains of Asset Management including Life Cycle Costing (LCC) as a decision-making criterion. However, LCC as a decision-making criterion should be applied on an entire substation taking into account all of the potential cost influences for the purpose of achieving of an effective substation management. Asset management as a decision-making process should be observed within a larger context and should be more focused on risk management, as all real decisions include an element of risk due to present uncertainties. Two promising avenues are explored in regards to more comprehensive and rigorous up-front planning through usage of Information Technology (IT). While up-front planning falls under the domain of Lean philosophy, Building Information Modeling (BIM) falls under the category of agile decisionsupport tools. Utilization of both is explored from a perspective of design-uncertainties under both product and process design. Standard specifications and standard designs are another form of applied Lean Philosophy that reduces design-uncertainty and variability. However, a range of technical solutions stemming out of the standardization can be quite wide. Customization involves specification and design of new / innovative designs with wide range of technical solutions as well. Due to external pressures focused on shortening of the project delivery time, there is a need for a faster project time throughput. This is reflected in the form of a requirement for more rapid engineering decision-making and faster decision cycles. Streamlining of a decision-making process related to the engineering is all about engineers’ awareness of the situation from the project level perspective coupled with utilization of decision-support tools for creation and reuse of knowledge. Plan – Do – Study – Orient (PDSO) cycle is a decisionmaking model that supports creation and reusability of knowledge along with providing an explanation in regards to the time dimension relating to decision-making, and as such is presented in this paper. The rigid busbar system design is an iterative process influenced by many factors, defined either as design variables or design constraints. As rigid busbars are gaining more popularity for both greenfield and brownfield investments, the rigid busbar system design is explored from a perspective of decision-making streamlining. The case of the rigid busbar system design of El Chaparral project in El Salvador is given

Evaluation of the stimulatory effect of Epimedium alpinum L. methanolic extract on the immune response in vivo

The effect of the methanolic extract of the underground parts of Epimedium alpinum L. (MEEA) on the immune response to Keyhole Limpet Hemocyanine (KLH) or alloantigens in vivo was studied in AO rats. Immunization of experimental animals with KLH or allogeneic lymphocytes together with MEEA was followed by an increase in cellularity of draining lymph nodes (LN) and enhanced proliferation of LN lymphocytes after their restimulation with specific antigens in vitro, compared to control rats immunized without MEEA. These effects correlated with an increase in relative values of B, MHC class II+, CD25(+) and CD71(+) cells, whereas percentages of T cells and both subsets of T cells (CD4(+) and CD8(+)) were not significantly altered. As a consequence of higher LN cellularity, total numbers of all cell subsets in the MEEA-treated group of rats were significantly increased, compared to the corresponding control. The addition of MEEA together with KLH in vitro to LN lymphocytes of rats immunized with KLH or KLH and MEEA in vivo was manifested by significant increase (0.1 mu g/ml of MEEA) and decrease (50 mu g/ml and 100 mu g/ml of MEEA) of cell proliferation, respectively. However, when LN lymphocytes from rats, immunized in vivo with KLH and MEEA, were stimulated in vitro with MEEA together with an anti-alpha beta T cell receptor monoclonal antibody (R73), their proliferation was siginificantly inhibited. Taken together, obtained results suggest that MEEA possesses immunostimulatory activity in vivo, but some components from the extract exert immunosuppressive effects in vitro on previously in vivo activated T cells